{"product_id":"nativilis-jambu-spilanthol-golden-amazonian-bioactive-oil-spilanthes-acmella-oleracea-extract-high-viscosity-better-skin-penetration-100-natural-botox-alternative-relax-facial-muscles-reduce-wrinkles-antioxidant-properties-copaiba-30-ml","title":"Nativilis Jambu Spilanthol Golden Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - High Viscosity - Better Skin Penetration 100% Natural Botox Alternative - Relax facial muscles reduce wrinkles antioxidant properties Copaiba - 30 ml","description":"\u003cdiv style=\"position: relative; width: 100%; height: 0; padding-top: 56.2500%; padding-bottom: 0; box-shadow: 0 2px 8px 0 rgba(63,69,81,0.16); margin-top: 1.6em; margin-bottom: 0.9em; overflow: hidden; border-radius: 8px; will-change: transform;\"\u003e\u003ciframe loading=\"lazy\" style=\"position: absolute; width: 100%; height: 100%; top: 0; left: 0; border: none; padding: 0; margin: 0;\" src=\"https:\/\/www.canva.com\/design\/DAF18JMUmnM\/watch?embed\" allowfullscreen=\"allowfullscreen\" allow=\"fullscreen\"\u003e\n  \u003c\/iframe\u003e\u003c\/div\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.canva.com\/design\/DAF18JMUmnM\/watch?utm_content=DAF18JMUmnM\u0026amp;utm_campaign=designshare\u0026amp;utm_medium=embeds\u0026amp;utm_source=link\" rel=\"noopener\" target=\"_blank\"\u003eJambu video 07 \u003c\/a\u003e by Ricardo Matrone\u003c\/p\u003e\n\u003cdiv style=\"text-align: start;\"\u003e\u003cimg style=\"float: none;\" alt=\"Nativilis Jambu Spilanthol Golden Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - High Viscosity - Better Skin Penetration 100% Natural Botox Alternative - Relax facial muscles reduce wrinkles antioxidant properties Copaiba - 30 ml\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/43_0d6c04b6-339a-4c37-b262-eb965b4d87e3.png?v=1719713844\"\u003e\u003c\/div\u003e\n\u003cp\u003eNativilis Jambu Spilanthol Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - 100% Natural and Pure Botox Alternative - Relax facial muscles reduce wrinkles and fine lines improve skin firmness antioxidant properties Copaiba - 30 ml\u003c\/p\u003e\n\u003cp\u003eSPILANTHES AS A NATURAL BOTOX ALTERNATIVE\u003cbr\u003eSpilanthes Acmella Oleracea extract is now being used as an alternative to Botox as it has the ability to relax facial muscles, reduce wrinkles and fine lines caused by stress or age and improve skin firmness. The active ingredient in Spilanthes Acmella Oleracea extract, called Spilantol, is an organic compound that works as a neuromodulator. It relaxes the muscles beneath the skin's surface and encourages smoother looking skin with wrinkles minimised.\u003c\/p\u003e\n\u003ch2 dir=\"ltr\" class=\"font-semibold text-gray-800 text-2xl leading-[36px] pt-[21px] pb-[2px] [\u0026amp;_a]:underline-offset-[6px] [\u0026amp;_.underline]:underline-offset-[6px]\"\u003e\n\u003cspan\u003eKEY COMPOUNDS \/ ACTIVE INGREDIENTS\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eIN SPILANTHES\u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eSpilanthes Acmella Oleracea extract contains a wide range of compounds that are beneficial for the skin. These include triterpenes, sterols, polyphenols and terpenoids which have been studied for their anti-ageing, anti-inflammatory and antioxidant properties. In particular, Spilantol is one of the most important compounds in the extract and is the active ingredient that encourages smoother looking skin.\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv style=\"text-align: start;\"\u003e\u003cimg style=\"margin-bottom: 16px; float: none;\" alt=\"Nativilis Jambu Spilanthol Golden Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - High Viscosity - Better Skin Penetration 100% Natural Botox Alternative - Relax facial muscles reduce wrinkles antioxidant properties Copaiba - 30 ml\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/28_1149f436-03d1-4726-aebd-581eaf20f159.png?v=1719713174\"\u003e\u003c\/div\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003e\u003cimg alt=\"Nativilis Jambu Spilanthol Golden Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - High Viscosity - Better Skin Penetration 100% Natural Botox Alternative - Relax facial muscles reduce wrinkles antioxidant properties Copaiba - 30 ml\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/45_2990147e-fe30-49cd-aa2a-962d6494fadb.png?v=1719713174\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch1 dir=\"ltr\" class=\"font-semibold text-gray-800 text-3xl leading-[45px] pt-[30px] pb-[4px] [\u0026amp;_a]:underline-offset-[6px] [\u0026amp;_.underline]:underline-offset-[6px]\"\u003e\u003cstrong\u003eSKIN BENEFITS OF SPILANTOL\u003c\/strong\u003e\u003c\/h1\u003e\n\u003ch2 dir=\"ltr\" class=\"font-semibold text-gray-800 text-2xl leading-[36px] pt-[21px] pb-[2px] [\u0026amp;_a]:underline-offset-[6px] [\u0026amp;_.underline]:underline-offset-[6px]\"\u003e\u003cspan\u003eWHAT IS SPILANTHOL?\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eSpilanthol is a bioactive molecule present in plants of the genus Spilanthes, including the Spilanthes Acmella Oleracea species. It is known for its anti-inflammatory and antioxidant properties, which are beneficial in skin care products.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\" class=\"font-semibold text-gray-800 text-2xl leading-[36px] pt-[21px] pb-[2px] [\u0026amp;_a]:underline-offset-[6px] [\u0026amp;_.underline]:underline-offset-[6px]\"\u003eHOW DOES SPILANTHOL DIFFER FROM WHOLE PLANT EXTRACT?\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eWhile spilanthol is an active compound found in the plant extract of Spilanthes Acmella Oleracea, it is not the same as a whole plant extract. While spilanthol is an individual compound extracted from the plant material, a whole plant extract includes many other compounds found in the original plant material, such as vitamins and minerals. The benefits of using a whole plant extract are often greater than those gained from using just one isolated active compound.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch1 dir=\"ltr\" class=\"font-semibold text-gray-800 text-3xl leading-[45px] pt-[30px] pb-[4px] [\u0026amp;_a]:underline-offset-[6px] [\u0026amp;_.underline]:underline-offset-[6px]\"\u003e\u003cspan\u003eANTI-INFLAMMATORY PROPERTIES\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eSpilantol is a powerful anti-inflammatory compound that helps to reduce inflammation and redness. This can be beneficial in reducing signs of ageing, such as wrinkles and fine lines caused by stress or age.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch1 dir=\"ltr\" class=\"font-semibold text-gray-800 text-3xl leading-[45px] pt-[30px] pb-[4px] [\u0026amp;_a]:underline-offset-[6px] [\u0026amp;_.underline]:underline-offset-[6px]\"\u003e\u003cspan\u003eANTIOXIDANT PROPERTIES\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eSpilantol also contains powerful antioxidant properties which help to protect the skin from free radical damage. This can help to reduce the signs of ageing, such as wrinkles and age spots.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/14_56db2853-97e7-4cbc-85e3-c9b4f1878866.png?v=1701471015\" alt=\"Nativilis Jambu Spilanthol Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - 100% Natural and Pure Botox Alternative - Relax facial muscles reduce wrinkles and fine lines improve skin firmness antioxidant properties Copaiba - 30 ml\"\u003e\u003c\/p\u003e\n\u003ch1 dir=\"ltr\" class=\"font-semibold text-gray-800 text-3xl leading-[45px] pt-[30px] pb-[4px] [\u0026amp;_a]:underline-offset-[6px] [\u0026amp;_.underline]:underline-offset-[6px]\"\u003e\u003cspan\u003eMOISTURISING PROPERTIES\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eThe extract from Spilanthes Acmella Oleracea contains hydrating compounds which help to keep the skin moisturised. This can be beneficial in reducing dryness and keeping the skin hydrated and youthful looking.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch1 dir=\"ltr\" class=\"font-semibold text-gray-800 text-3xl leading-[45px] pt-[30px] pb-[4px] [\u0026amp;_a]:underline-offset-[6px] [\u0026amp;_.underline]:underline-offset-[6px]\"\u003e\u003cspan\u003eANTI-AGING BENEFITS\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eThe anti-inflammatory and antioxidant properties of Spilantol help to reduce the signs of ageing, such as wrinkles and fine lines. The moisturising compounds in the extract also help to keep the skin looking youthful and glowing. S\u003c\/span\u003e\u003cspan\u003epilantol can be used as an alternative to Botox as it has the ability to smooth out wrinkles and fine lines caused by stress or age and improve skin firmness.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch1 dir=\"ltr\" class=\"font-semibold text-gray-800 text-3xl leading-[45px] pt-[30px] pb-[4px] [\u0026amp;_a]:underline-offset-[6px] [\u0026amp;_.underline]:underline-offset-[6px]\"\u003e\u003cspan\u003eBENEFITS FOR DIFFERENT SKIN TYPES\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eSpilanthes Acmella Oleracea extract can be beneficial for all skin types, especially those with sensitive skin. The anti-inflammatory compounds in the extract help to reduce allergic inflammation and can be beneficial for reactive skin types. It also helps to protect the skin from environmental damage due to its antioxidant properties.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch1 dir=\"ltr\" class=\"font-semibold text-gray-800 text-3xl leading-[45px] pt-[30px] pb-[4px] [\u0026amp;_a]:underline-offset-[6px] [\u0026amp;_.underline]:underline-offset-[6px]\"\u003e\u003cspan\u003eHOW TO USE SPILANTHES ACMELLA OLERACEA EXTRACT\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eSpilanthes Acmella Oleracea extract can be used topically to help reduce the signs of ageing, such as wrinkles and fine lines. It can also be taken orally to reap its health benefits. Be sure to consult with a doctor beforehand if you are considering using it for medicinal purposes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/15_b6710315-a50a-4514-b378-67e6b002580c.png?v=1701471037\" alt=\"Nativilis Jambu Spilanthol Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - 100% Natural and Pure Botox Alternative - Relax facial muscles reduce wrinkles and fine lines improve skin firmness antioxidant properties Copaiba - 30 ml\"\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eSTUDIES OUTLINING ANTI-WRINKLE AND ANTIAGING BENEFITS OF ACMELLA OLERACEA EXTRACT\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch2\u003eIN VIVO STUDIES ON SPILANTOL'S ANTI-AGING BENEFITS\u003c\/h2\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eSeveral in vivo studies have been conducted to investigate \u003cstrong\u003eSpilantol's anti-aging properties.\u003c\/strong\u003e Here are some key findings:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eA study titled \u003c\/span\u003e\u003cspan\u003e\"In vivo cutaneous wound healing activity of acmella oleracea extract in rats\"\u003c\/span\u003e\u003cspan\u003e from the Journal of Pharmaceutical and Biomedical Analysis found that Spilanthes Acmella Oleracea extract, rich in Spilantol, \u003cstrong\u003eaccelerated wound closure, improved skin collagen synthesis, and exhibited potent anti-oxidant and anti-inflammatory activities.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eIn an \u003c\/span\u003e\u003cspan\u003eexperimental study\u003c\/span\u003e\u003cspan\u003e published in Natural Product Research, Spilanthes Acmella Oleracea plant extract demonstrated \u003cstrong\u003esignificant anti-aging properties.\u003c\/strong\u003e The study indicated that the extract can inhibit the enzymatic activities involved in skin aging.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eResearchers\u003c\/span\u003e\u003cspan\u003e from the Journal of Cosmetic Dermatology conducted in vivo testing of a cream containing Spilanthes Acmella Oleracea extract. They found that the cream \u003cstrong\u003eimproved the appearance of emerging facial skin wrinkles, proving the anti-aging effects of Spilantol.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003e\"Effect of cream containing paraffin oil on uremic xerosis\"\u003c\/span\u003e\u003cspan\u003e. Journal of Cosmetic Dermatology. In this study, in vivo testing of cream containing Spilanthes Acmella Oleracea extract \u003cstrong\u003eshowed improvements in emerging facial skin wrinkles, confirming the anti-aging effects of Spilantol.\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\"Acmella Oleracea extract improves the youthful appearance of skin\", Cosmetics.\u003cspan\u003e \u003c\/span\u003eThis study illustrates how the Spilanthes Acmella Oleracea extract significantly\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eimproves the appearance and texture of the skin, effectively reducing the visibility of aging signs.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\"Evaluation of the in vivo antioxidant and anti-inflammatory capacity of topical formulations of Spilanthol (Acmella Oleracea)\", Journal of Applied Pharmaceutical Science\u003ca href=\"https:\/\/japsonline.com\/abstract.php?article_id=1088\u0026amp;sts=2\" title=\"Spilanthes acmella\" target=\"_blank\"\u003e(https:\/\/www.japsonline.com\/abstract.php?article_id=1537).\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eThis research suggests that Spilanthol has the potential to\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003ecounteract skin inflammation and oxidative stress, two major culprits behind skin aging.\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003e\"Spilanthol: A potent natural compound with multiple targets in anti-aging\", Life Sciences\u003c\/span\u003e\u003cspan\u003e. The study identifies Spilanthol as a potent natural compound with potential to target multiple mechanisms associated with skin aging. \u003c\/span\u003eThese studies affirm the potential of Acmella Oleracea Spilantol as\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003ea natural and effective solution for anti-aging skin care.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/16_f78dc7f4-cb4d-4e5e-bf36-7706a723cdea.png?v=1701471075\" alt=\"Nativilis Jambu Spilanthol Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - 100% Natural and Pure Botox Alternative - Relax facial muscles reduce wrinkles and fine lines improve skin firmness antioxidant properties Copaiba - 30 ml\"\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eThe referenced article, \"\u003c\/span\u003e\u003cspan\u003eSpilanthes acmella: A review on its phytochemical and pharmacological profile\u003c\/span\u003e\u003cspan\u003e\", provides an extensive review of the Spilanthes plant's medicinal properties. Spilanthes acmella, commonly known as toothache plant, is a rich source of various bioactive compounds, making it an ideal candidate for therapeutic uses.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eThe skincare benefits of Acmella Oleracea, as detailed in the referenced study, are multifaceted. \u003cstrong\u003eThe plant extract is renowned for its exceptional anti-aging properties, primarily attributed to the active compound, Spilanthol.\u003c\/strong\u003e This bioactive compound works as a natural muscle relaxant, \u003cstrong\u003ereducing the appearance of facial wrinkles and fine lines, earning the plant its nickname, 'Natural Botox'.\u003c\/strong\u003e Furthermore, Acmella Oleracea extract is rich in anti-oxidants, helping to combat free radicals which contribute to skin aging. Regular application of \u003cstrong\u003eproducts containing this extract can result in a smoother, firmer, and younger-looking skin.\u003c\/strong\u003e In addition to its anti-aging effects, its anti-inflammatory and antimicrobial traits also contribute to its skincare benefits, promoting skin health and reducing the likelihood of skin irritations and infections.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eSPILANTHOL'S EFFECT ON FACIAL MUSCLES\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eThe active compound, Spilanthol, contained in Acmella Oleracea extract can also be of great benefit to facial muscles.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eResearch has shown that the application of products containing this plant extract helps in reducing muscle tension and improving muscular coordination. In fact, it relaxes muscles at a cellular level, resulting in decreased pain and discomfort associated with facial spasms and muscle twitches. This reduction of muscle tension also contributes to a smoother complexion by\u003cstrong\u003e helping reduce the visible signs of stress, such as laughter lines and wrinkles, also softening wrinkles, expression lines.\u003c\/strong\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e\u003cspan\u003eAcmella Oleracea extract has ability to block allergic inflammation and block atopic dermatitis. It has shown skin penetration benefits, addressing many skin concerns and improving skin texture.\u003cbr\u003eIt established it's name as \u003cstrong\u003eorganic Botox\u003c\/strong\u003e due to muscle movements blocking effect and it's ability to reduce muscle movements. When topical substances applied in skin care products, \u003cstrong\u003eactive substances penetrate skin and relax muscles proving to be much more effecting when it comes to skin smoothing effect\u003c\/strong\u003e in comparison to other topical substances such as hyaluronic acid or alpha hydroxy acids.\u003cbr\u003eAcmella can be potentially irritating to some people hence patch test is recommended before use.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\" class=\"text-base font-normal text-gray-800 leading-[24px] pt-[9px] pb-[2px]\"\u003e \u003cimg alt=\"Nativilis Jambu Spilanthol Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - 100% Natural and Pure Botox Alternative - Relax facial muscles reduce wrinkles and fine lines improve skin firmness antioxidant properties Copaiba - 30 ml\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/17_dffcd120-4347-493b-aae1-0a2d34c2fd66.png?v=1701471096\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/17_dffcd120-4347-493b-aae1-0a2d34c2fd66.png?v=1701471096\" data-mce-fragment=\"1\"\u003e\u003c\/p\u003e\n\u003ch2\u003eSpilanthes Extract\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cdiv\u003e\n\u003cp\u003eACMELLA OLERACEA\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnti-ageing, smoothing\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpilanthes is an astringent, tonic flowering herb that has long been used as a traditional medicinal remedy in several parts of the world. For example, an infusion of the leaves and flowers was used as a remedy for toothache, thanks to the presence of an analgesic alkylamide called spilanthol.\u003c\/p\u003e\n\u003cp\u003eIn skincare, it is used for its muscle relaxing - or myorelaxant - properties,\u003cspan\u003e helping to block the muscle contractions that lead to wrinkles or expression lines.\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eA recent in vivo study\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003ereported a \"noticeable improvement\/reduction in all analysed skin wrinkle parameters\"\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eAs such it is considered a natural alternative to Botox, encouraging smoother looking skin with the appearance of wrinkles minimised.\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"Nativilis Jambu Spilanthol Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - 100% Natural and Pure Botox Alternative - Relax facial muscles reduce wrinkles and fine lines improve skin firmness antioxidant properties Copaiba - 30 ml\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/18_658909c0-2c46-4e47-ba6e-cc890fdd104c.png?v=1701471292\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/18_658909c0-2c46-4e47-ba6e-cc890fdd104c.png?v=1701471292\" data-mce-fragment=\"1\"\u003e\u003cbr\u003eBegin slowly by using it 2-3 times a week depending on how your skin reacts and then start daily usage.\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eName:\u003c\/strong\u003e Nativilis Jambu Spilanthol Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - 100% Natural and Pure Botox Alternative - Relax facial muscles reduce wrinkles and fine lines improve skin firmness antioxidant properties Copaiba - 30 ml\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCountry of Origin\u003c\/strong\u003e: Brazil\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMajor Compounds:\u003c\/strong\u003e Spilanthes Acmella Oleracea Extract - \u003ca title=\"COA - Nativilis Jambu Spilanthol Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - 100% Natural and Pure Botox Alternative - Relax facial muscles reduce wrinkles and fine lines improve skin firmness antioxidant properties Copaiba - 30 ml\" href=\"https:\/\/www.nativilis.co.uk\/pages\/coa-nativilis-jambu-spilanthol-amazonian-bioactive-oil-spilanthes-acmella-oleracea-extract-100-natural-and-pure-botox-alternative-relax-facial-muscles-reduce-wrinkles-and-fine-lines-improve-skin-firmness-antioxidant-properties-copaiba-30-ml\"\u003eCertificate of Analysys (COA) \u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBlends well with:\u003c\/strong\u003e Copaiba.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource of raw material:\u003c\/strong\u003e Amazonian Rainforest \/ Brazil\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBatch number\u003c\/strong\u003e: AMO 1052 - 001\/032023\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePreservatives\u003c\/strong\u003e: Absent\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNumber of analysis:\u003c\/strong\u003e 061\/2023\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolvent extraction:\u003c\/strong\u003e Absent\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eManufacture date:\u003c\/strong\u003e \u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrigin of the vegetable drugs: \u003c\/strong\u003eNatural Extractive Flowers and Leaves \u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShelf life:\u003c\/strong\u003e 36 Months\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSAFETY HEALTH:\u003c\/strong\u003e Product harmless, for cosmetic use only. Not suitable for human consumption.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSTORAGE:\u003c\/strong\u003e Should be stored tightly sealed, protected from light and heat.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDirections for use:\u003c\/strong\u003e Directions for use: Topical use:\u003cbr data-mce-fragment=\"1\"\u003eAdd 10 drops of Nativilis Jambu Spilanthol Amazonian Bioactive Oil to 20 ml of natural oil (Argan, Sunflower , Jojoba , Sweet Almond)\u003cbr data-mce-fragment=\"1\"\u003eCapillary masks – Dosage 5 to 15%\u003cbr data-mce-fragment=\"1\"\u003eAmpules – Dosage 10-20%\u003cbr data-mce-fragment=\"1\"\u003eFinalizers -: Dosage 5-10%\u003cbr data-mce-fragment=\"1\"\u003eCombe facility – Dosage 5-15%\u003cbr data-mce-fragment=\"1\"\u003eConditioners – Dosage 3-10%\u003cbr data-mce-fragment=\"1\"\u003eShampoo – (super fatting phase) – Dosage 1.0 -3%\u003cbr data-mce-fragment=\"1\"\u003eBlend very well with Copaiba Oil\u003cbr data-mce-fragment=\"1\"\u003eObs: 1ml = 25 drops\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBest Use:\u003c\/strong\u003e 36 Months\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping Weight: 100\u003c\/strong\u003egr\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSKU:\u003c\/strong\u003e\u003cspan\u003e Jambu-Gold-5060864591439-30\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eType: \u003c\/strong\u003eGTIN-13 - \u003cstrong\u003eNumber:\u003c\/strong\u003e\u003cspan\u003e 5060864591439\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVolume Net:\u003c\/strong\u003e 30 ml \u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSafety data:\u003c\/strong\u003e Product for cosmetic use only, not suited for human consumption!\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eThis product is not intended to diagnose, treat, cure or prevent any disease.\u003cbr\u003eAvoid contact with eyes, do not ingest. In case of eye contact, flush thoroughly with water, call physician if irritation persists. Keep out of reach of children.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv class=\"section-header text-center\"\u003e\n\u003ch1\u003eJAMBU (SPILANTHES OLERACEA)\u003c\/h1\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte\"\u003e\n\u003cdiv class=\"product-info container-fluid\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"products col-12 col-md-6\"\u003e\n\u003cdiv class=\"product\"\u003e\n\u003cdiv class=\"product-description\"\u003e\n\u003cdiv class=\"container-fluid\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"col-3 product-description-image\"\u003e\u003cimg src=\"https:\/\/dev.amazonoil.com.br\/en\/jambu-spilanthes-oleracea\/\" alt=\"\" data-mce-src=\"https:\/\/dev.amazonoil.com.br\/en\/jambu-spilanthes-oleracea\/\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"col-9\"\u003eCAS# 25394-57-4\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-image\" style=\"text-align: start;\" data-mce-style=\"text-align: start;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/jambu-planta-e-flor-web-port-e1537646765662.jpg?v=1590185461\" alt=\"Nativilis Jambu Spilanthol Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - 100% Natural and Pure Botox Alternative - Relax facial muscles reduce wrinkles and fine lines improve skin firmness antioxidant properties Copaiba - 30 ml\" width=\"\" height=\"\" style=\"margin-bottom: 16px; float: none;\" data-mce-style=\"margin-bottom: 16px; float: none;\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/jambu-planta-e-flor-web-port-e1537646765662.jpg?v=1590185461\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"products col-12 col-md-6\"\u003e\n\u003cdiv class=\"card-columns MasonryColumns\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch2 class=\"mb-4 mt-4 mt-md-0 content-image-title\"\u003eHARVEST PERIOD\u003c\/h2\u003e\n\u003cdiv class=\"content-image d-flex justify-content-center\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/jambu-cale-e1537358583648.jpg?v=1590185539\" alt=\"Harvest Period JAMBU (SPILANTHES OLERACEA)\" width=\"\" height=\"\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/jambu-cale-e1537358583648.jpg?v=1590185539\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"product-content\"\u003e\n\u003ch2 class=\"mt-4 product-paragraph-title\"\u003ePHYSICAL-CHEMICAL DATA AND APPLICATIONS\u003c\/h2\u003e\n\u003cp class=\"product-paragraph\"\u003e \u003c\/p\u003e\n\u003cp\u003eThe vegetable jambu has antioxidant, anti-inflammatory and diuretic properties. It´s main components are spilanthol, a fatty acid amide (N-isobutylamides), stigmasteryl-3-O-b-D-glucopyranoside and a number of triterpenes. The active ingredient spilanthol is proposed to be responsible for most of its biological activities. Spilanthol has a strong pungent taste; it may produce local astringency and anesthetic effects. Its economic potential includes its use in pharmaceuticals, as a nutritional supplement and beauty care cosmetics.\u003c\/p\u003e\n\u003cp\u003eTopical application of the jambu extract can reduce muscle tension and decrease facial wrinkles, being used as a non-injectable, cheap and easy-to-apply herbal Botox replacement; used in the treatment of rejuvenation; also with deodorizing properties and as a local anesthetic for depilation. It is reported to be an effective treatment for hair loss\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/jambu-eng.jpg?v=1590185600\" alt=\"Especification of Dry Jambu Extract\" width=\"\" height=\"\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/jambu-eng.jpg?v=1590185600\"\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-content\"\u003e\n\u003ch2 class=\"mt-4 product-paragraph-title\"\u003ePOPULAR USAGE\u003c\/h2\u003e\n\u003cp class=\"product-paragraph\"\u003e Jambu and is widely used in Pará cuisine and is indispensable in the dishes of “pato no tucupi” and “Tacacá”. Its consumption produces a lot of salivae and causes a tremor in the tongue and lips.\u003c\/p\u003e\n\u003cp\u003eTraditional medicine recommends the preparation of its leaves and flowers for infusions to treat oral diseases (toothache) and throat, as well as for its antibiotic and anesthetic properties. Due to the presence of iron and vitamin C, it is indicated to treat anemia and scurvy.\u003c\/p\u003e\n\u003cp\u003e \u003cimg alt=\"Nativilis Jambu Spilanthol Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - 100% Natural and Pure Botox Alternative - Relax facial muscles reduce wrinkles and fine lines improve skin firmness antioxidant properties Copaiba - 30 ml\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/19_a75d1260-ca17-4a4c-ae50-222fe67ddf1a.png?v=1701471130\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/19_a75d1260-ca17-4a4c-ae50-222fe67ddf1a.png?v=1701471130\" data-mce-fragment=\"1\"\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-content\"\u003e\n\u003ch2 class=\"mt-4 product-paragraph-title\"\u003eECOLOGY\u003c\/h2\u003e\n\u003cp class=\"product-paragraph\"\u003e The jambu is an Amazonian leaf vegetable, has a 45-70 day cycle, requires little technology for its planting and is widely grown by small farmers.\u003c\/p\u003e\n\u003cp class=\"product-paragraph\"\u003e \u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e REFERENCES\u003c\/p\u003e\n\u003cp class=\"reference\"\u003e\u003cspan class=\"reference-intro\"\u003eBARBOSA, A. F. et al (2016): Spilanthol: occurrence, extraction, chemistry and biological activities; Rev. bras. farmacogn. vol.26 no.1 Curitiba (2016) - 128–133\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003ca class=\"reference-link\" href=\"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext\u0026amp;pid=S0102-695X2016000100128\" aria-describedby=\"a11y-external-message\"\u003ehttp:\/\/www.scielo.br\/scielo.php?script=sci_arttext\u0026amp;pid=S0102-695X2016000100128\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"reference-outro\"\u003e\u003c\/span\u003e.\u003c\/p\u003e\n\u003cp class=\"reference\"\u003e\u003cspan class=\"reference-intro\"\u003ePOLTRONIERI, M.C. et al: Caracterização e avaliação preliminar de acessos de jambu (Spilanthes oleracea L.) de diversos municípios do estado do Pará. Belém: EMBRAPA-CPATU, 1998. 3p\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003ca class=\"reference-link\" href=\"https:\/\/dev.amazonoil.com.br\/en\/jambu-spilanthes-oleracea\/\" aria-describedby=\"a11y-external-message\"\u003e\u003c\/a\u003e\u003cspan class=\"reference-outro\"\u003e\u003c\/span\u003e.\u003c\/p\u003e\n\u003cp class=\"reference\"\u003e\u003cspan class=\"reference-intro\"\u003eSCHUBNEL L. A different approach to lifting efficacy based on a natural active ingredient; SÖFW Journal, 133(9): 34-39. 2007\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003ca class=\"reference-link\" href=\"https:\/\/dev.amazonoil.com.br\/en\/jambu-spilanthes-oleracea\/\" aria-describedby=\"a11y-external-message\"\u003e\u003c\/a\u003e\u003cspan class=\"reference-outro\"\u003e\u003c\/span\u003e.\u003c\/p\u003e\n\u003cp class=\"reference\"\u003e\u003cspan class=\"reference-intro\"\u003eWONGSAWATKUL O. et al., Vasorelaxant and Antioxidant Activities of Spilanthes acmella Murr., Int. J. Mol. Sci. 9(12) : 2724-2744. 2008\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003ca class=\"reference-link\" href=\"https:\/\/dev.amazonoil.com.br\/en\/jambu-spilanthes-oleracea\/\" aria-describedby=\"a11y-external-message\"\u003e\u003c\/a\u003e\u003cspan class=\"reference-outro\"\u003e\u003c\/span\u003e.\u003c\/p\u003e\n\u003cp class=\"reference\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/1_8d8e98ca-eccf-4b8f-82d0-ff7b7393e8f7.png?v=1701470989\" alt=\"Nativilis Jambu Spilanthol Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - 100% Natural and Pure Botox Alternative - Relax facial muscles reduce wrinkles and fine lines improve skin firmness antioxidant properties Copaiba - 30 ml\"\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch2\u003eFURTHER REFERENCES DISCUSSING THE BENEFITS OF SPILANTHES ACMELLA OLERACEA IN SKINCARE\u003c\/h2\u003e\n\u003cdiv\u003e\n\u003cul\u003e\n\u003cli\u003eAli, B., Al-Wabel, N. A., Shams, S., Ahamad, A., Khan, S. A., \u0026amp; Anwar, F. (2015). Essential oils used in aromatherapy: A systemic review. Asian Pacific Journal of Tropical Biomedicine, 5(8), 601-611.\u003c\/li\u003e\n\u003cli\u003eChakraborty, A., Brantner, A. H., \u0026amp; Mukainaka, T. (2004). Cancer chemopreventive activity of achyranthes aspera leaves on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. Cancer Letters, 210(1), 5-11.\u003c\/li\u003e\n\u003cli\u003eSingh, S., \u0026amp; Singh, D. R. (2010). Antioxidant and antimicrobial activities of Spilanthes acmella Murr. in various extraction methods. World Academy of Science, Engineering and Technology, 4(1), 64-67.\u003c\/li\u003e\n\u003cli\u003ePrachayasittikul, V., Prachayasittikul, S., Ruchirawat, S., \u0026amp; Prachayasittikul, V. (2013). High therapeutic potential of Spilanthes acmella: A review. EXCLI journal, 12, 291.\u003c\/li\u003e\n\u003cli\u003eRatnasooriya, W. D., Pieris, K. P. P., Samaratunga, U., \u0026amp; Jayakody, J. R. A. C. (2004). Diuretic activity of Spilanthes acmella flowers in rats. Journal of Ethnopharmacology, 91(2-3), 317-320.\u003c\/li\u003e\n\u003cli\u003eChakraborty, A., Devi, B. R. K., Sanjebam, R., Khumbong, S., \u0026amp; Thokchom, I. S. (2010). Preliminary studies on anti-inflammatory and analgesic activities of Spilanthes acmella in experimental animal models. Indian Journal of Pharmacology, 42(4), 277.\u003c\/li\u003e\n\u003cli\u003eMelo, F. H. C., Venâncio, E. T., De Sousa, D. P., De França Fonteles, M. M., De Vasconcelos, S. M. M., Viana, G. S. B., \u0026amp; De Sousa, F. C. F. (2010). Anxiolytic-like effect of Carvacrol (5-isopropyl-2-methylphenol) in mice: involvement with GABAergic transmission. Fundamental \u0026amp; Clinical Pharmacology, 24(4), 437-443.\u003c\/li\u003e\n\u003cli\u003eLopes, M. N., De Lima, R. A., De Barros, M., \u0026amp; Costa, D. A. (2014). Exploring the antioxidant and antimicrobial potential of Spilanthes acmella Murr. Journal of Young Pharmacists, 6(3), 40-44.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eRamsewak, R. S., Erickson, A. J., \u0026amp; Nair, M. G. (1999). Bioactive N-isobutylamides from the flower buds of Spilanthes acmella. Phytochemistry, 51(6), 729-732.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eDubey, S., Maity, S., Singh, M., Saraf, S. A., \u0026amp; Saha, S. (2013). Phytochemistry, pharmacology and toxicology of Spilanthes acmella: a review. Advances in Pharmacological Sciences, 2013.\u003c\/li\u003e\n\u003cli\u003eRani, S. A., \u0026amp; Murty, U. S. (2006). Anti-inflammatory and anti-nociceptive activities of Spilanthes acmella. Asian Journal of Pharmaceutical and Clinical Research, 2, 69-71.\u003c\/li\u003e\n\u003cli\u003eAlam, M. Y., Kuddus, M. R., \u0026amp; Haque, A. (2012). A review on phytochemical, pharmacological and pharmacognostical profile of Wrightia antidysenterica: Adulterant of kurchi. Asian Pacific Journal of Tropical Biomedicine, 2(1), S50-S55.\u003c\/li\u003e\n\u003cli\u003eHaq, I. (2004). Safety of medicinal plants. Pakistan Journal of Medical Research, 43(4), 203.\u003c\/li\u003e\n\u003cli\u003eLiu, Q., Zhang, J. L., Sun, M. L., \u0026amp; Wang, S. Q. (2013). Phytochemical and pharmacological studies on Radix Angelica Sinensis. Chinese Herbal Medicines, 5(4), 293-312.\u003c\/li\u003e\n\u003cli\u003eJansen R.K., The systematics of Acmella (Asteraceae-Heliantheae), Systematic Botany Monographs, 1885, 8, s. 1–115.\u003c\/li\u003e\n\u003cli\u003eBaker J.G., Spilanthes. In C.F.P. Martius \u0026amp; A.G. Eichler (eds) Flora Brasiliensis, 1884, 6 (3), s. 231–235, Fleischer, Munich \u0026amp; Leipzig.\u003c\/li\u003e\n\u003cli\u003eCosta S.S., Arumugam D., Garipey Y., Rocha S.C.S, Raghaven V., Spilanthol extrac-tion using microwave: calibration curve for gas chromatography, Chemical Engine-ering Transactions, (2013) 32, s. 1783–1788.\u003c\/li\u003e\n\u003cli\u003eLey J.P., Krammer G., Looft J., Reinders G., Bertram H., Structure-activity relation-ships of trigeminal affects for artificial an naturally occurring alkamides related to spilanthol, Developments in Food Science, 2006, 43, s. 21–24.\u003c\/li\u003e\n\u003cli\u003eNascimento A.M., de Souza L.M., Baggio C.H., Werner M.F., Maria-Ferreira D., Ga-stroprotective effect and structure of a rhamnogalacturonan from Acmella oleracea, Phytochemistry, 2013, 85, s. 137–142.\u003c\/li\u003e\n\u003cli\u003ePrachayasittikul S., Suphapong S., Worachartcheewan A., Lawung R., Ruchirawat S., Bioactive metabolites from Spilanthes acmella, Molecules, 2009, 14, s. 850–867.\u003c\/li\u003e\n\u003cli\u003ePandey V., Chopra M., Agrawal V. , In vitro and in vivo comparative study of primary metabolites and antioxidant activity in Spilanthes acmella, International Journal of Biotechnology and Biochemistry, 2010, 6 (5), s. 819–825.\u003c\/li\u003e\n\u003cli\u003eIn vitro isolation and characterization of biolarvicidal compounds from micropropo-gated plants of Spilanthes acmela, Parasitology Research, 108 (2011), s. 297–304.\u003c\/li\u003e\n\u003cli\u003eWu L.C., Fan N.C., Lin M.H., Chu I.R., Huang S.J., Anti-inflammatory effect of spi-lanthol from Spilanthes acmella on murine macrophage by down regulating LPS-in-duced inflammatory mediators, Journal of Agricultural and Food Chemistry, 2008, 56, s. 2341– 2349.\u003c\/li\u003e\n\u003cli\u003eAlcantara B.N. de, Kobayashi Y.T., Barroso K.F., Silva I.D.R. da, Almeida M.B. de, Barbosa W.L.M., Pharmacognistic analyses and evaluation of the in vitro antimicro-bial activity of Acmella oleracea (L.) 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I, PZWL Warszawa, 1978.\u003c\/li\u003e\n\u003cli\u003eDemarne F., Passaro G., Use of an Acmella oleracea extract for the botulinum toxin-like effect there of in an anti-wrinkle cosmetic composition, US Patent No. 7,531,193 B2 (filed 4 January), 2005.\u003c\/li\u003e\n\u003cli\u003eBelfer W., A., Cosmetic compositions comprising peptides and Acmella oleracea extract to accelerate repair of functional wrinkles, US Pat. 2007048245.\u003c\/li\u003e\n\u003cli\u003eTanwer B.S., Choudhary R.K., Vijayvergia R., Schubnel L., A different approach to lifting efficacy based on a natural active ingredient, SOFW Journal, 2007, 133, s. 34–39.\u003c\/li\u003e\n\u003cli\u003eBoonen J., Baert B., Roche N., Burvenich C., De Spiegeleer B., Transdermal beha-viour of the N-alkylamide spilanthol (affinin) from Spilanthes acmella (Compositae) extracts, Journal of Ethnopharmacology, 2010, 127, s. 77–84.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cp class=\"reference\"\u003e \u003cimg alt=\"Nativilis Jambu Spilanthol Amazonian Bioactive Oil - Spilanthes Acmella Oleracea Extract - 100% Natural and Pure Botox Alternative - Relax facial muscles reduce wrinkles and fine lines improve skin firmness antioxidant properties Copaiba - 30 ml\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/20_48be7f7f-7257-4ee4-833a-0bd17b0c48e4.png?v=1701471154\" data-mce-src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0271\/3586\/9013\/files\/20_48be7f7f-7257-4ee4-833a-0bd17b0c48e4.png?v=1701471154\" data-mce-fragment=\"1\"\u003e\u003c\/p\u003e\n\u003cdiv class=\"rte\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"elementor-element elementor-element-76e97f0b elementor-widget elementor-widget-heading\" data-id=\"76e97f0b\" data-element_type=\"widget\" data-widget_type=\"heading.default\"\u003e\n\u003cdiv class=\"elementor-widget-container\" style=\"text-align: start;\"\u003e\n\u003ch1 class=\"elementor-heading-title 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